I mentioned in Motojournalism Book Two that having quick access to your camera gear is key. You're gonna miss a ton of great photos if it's a hassle to get your camera out.
Gus from Florida sent me a few shots of his tankbag setup. He's found a great way of keeping things safe and organized using the padded dividers of an old camera bag:
Looks like it works great! One more thing you can do is attach the shoulder strap from the camera bag onto the D rings of the tankbag to make it easier to carry when you're walking around.
Here's a shot of my setup on the road: Same Wolfman Explorer bag, works perfectly on the KLR650.
I keep a sweater or scarf underneath the camera and lenses. I have the Nikkor 28mm 2.8 on the Nikon body, and the 85mm 1.8 Nikkor and 11-16 2.8 Tokina are kept in the LowePro slip-lock cases.